Low-complexity regions within protein sequences have position-dependent roles
نویسندگان
چکیده
منابع مشابه
Increased Substitution Rates Surrounding Low-Complexity Regions within Primate Proteins
Previous studies have found that DNA-flanking low-complexity regions (LCRs) have an increased substitution rate. Here, the substitution rate was confirmed to increase in the vicinity of LCRs in several primate species, including humans. This effect was also found among human sequences from the 1000 Genomes Project. A strong correlation was found between average substitution rate per site and di...
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MOTIVATION Pair-wise alignment of protein sequences and local similarity searches produce many false positives because of compositionally biased regions, also called low-complexity regions (LCRs), of amino acid residues. Masking and filtering such regions significantly improves the reliability of homology searches and, consequently, functional predictions. Most of the available algorithms are b...
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Arithmetical complexity of a sequence is the number of words of length n that can be extracted from it according to arithmetic progressions. We study uniformly recurrent words of low arithmetical complexity and describe the family of such words having lowest complexity. Mathematics Subject Classification. 68R15.
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MOTIVATION Local compositionally biased and low complexity regions (LCRs) in amino acid sequences have initially attracted the interest of researchers due to their implication in generating artifacts in sequence database searches. There is accumulating evidence of the biological significance of LCRs both in physiological and in pathological situations. Nonetheless, LCR-related algorithms and to...
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ژورنال
عنوان ژورنال: BMC Systems Biology
سال: 2010
ISSN: 1752-0509
DOI: 10.1186/1752-0509-4-43